MovDisordV3, Main, Exploration, bibRecord, 001025

Placebo Effect Characteristics Observed in a Single, International, Longitudinal Study in Huntington's Disease

Identifieur interne : 001025 ( Main/Exploration ); précédent : 001024; suivant : 001026

Placebo Effect Characteristics Observed in a Single, International, Longitudinal Study in Huntington's Disease

Auteurs : Esther Cubo [Espagne] ; Miguel Gonzalez [Espagne] ; Inés Del Puerto [Espagne] ; Justo Garcia De Yebenes [Espagne] ; Olga Fernández Arconada [Espagne] ; José Maria Trejo Gabriel Y Galan [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0198679

Descripteurs français

Pascal (Inist)
- Chorée de Huntington, Pathologie du système nerveux, Effet placebo, Essai clinique, Placebo.

English descriptors

KwdEn :
- Clinical trial, Huntington disease, Nervous system diseases, Placebo, Placebo effect.

Abstract

Background: Classically, clinical trials are based on the placebo-control design. Our aim was to analyze the placebo effect in Huntington's disease. Methods: Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it. Results: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41 % (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time. Conclusions: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function.

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Curation: 002A94
to stream PascalFrancis, to step Checkpoint: 000098
to stream Main, to step Merge: 001077
to stream Main, to step Curation: 001025

Le document en format XML

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<author><name sortKey="Trejo Gabriel Y Galan, Jose Maria" sort="Trejo Gabriel Y Galan, Jose Maria" uniqKey="Trejo Gabriel Y Galan J" first="José Maria" last="Trejo Gabriel Y Galan">José Maria Trejo Gabriel Y Galan</name>
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<front><div type="abstract" xml:lang="en">Background: Classically, clinical trials are based on the placebo-control design. Our aim was to analyze the placebo effect in Huntington's disease. Methods: Placebo data were obtained from an international, longitudinal, placebo-controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One-hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it. Results: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41 % (last visit). Nondepressed patients with better functional status were most likely to be placebo-responders over time. Conclusions: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function.</div>
</front>
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<name sortKey="Trejo Gabriel Y Galan, Jose Maria" sort="Trejo Gabriel Y Galan, Jose Maria" uniqKey="Trejo Gabriel Y Galan J" first="José Maria" last="Trejo Gabriel Y Galan">José Maria Trejo Gabriel Y Galan</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Placebo Effect Characteristics Observed in a Single, International, Longitudinal Study in Huntington's Disease

Placebo Effect Characteristics Observed in a Single, International, Longitudinal Study in Huntington's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri